X0306 4 2017-08-08 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001531047 Miao Graham G C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 1 1 0 0 President and CFO Common Stock 2017-08-08 4 A 0 6667 0 A 64035 D Stock Option (right to buy) 2.78 2017-08-08 4 A 0 20000 0 A 2027-08-08 Common Stock 20000 20000 D Represents a grant of restricted share units that vest in four equal annual installments of approximately 1,667 shares over a four-year period, with the first installment vesting on August 8, 2018, which is the one-year anniversary of the grant date. Consists of (x) 13,701 shares of common stock and (y) the unvested amount of previously-awarded restricted share units that vest in two equal installments of approximately 21,833 shares, with the next installment vesting on July 26, 2018 and the final installment vesting on July 26, 2019 and (z) the unvested amount of the restricted share units that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 5,000 shares over a four-year period, with the first installment vesting at the close of business on August 8, 2018, which is the one-year anniversary of the grant date. /s/ Graham G. Miao 2017-08-09