X0306 4 2017-08-08 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001337409 Sedor John A 10 N. PARK PLACE MORRISTOWN NJ 07960 1 1 0 0 Chairman of Board and CEO Common Stock 2017-08-08 4 A 0 10000 0 A 127807 D Stock Option (right to buy) 2.78 2017-08-08 4 A 0 30000 0 A 2027-08-08 Common Stock 30000 30000 D Represents a grant of restricted share units that vest in four equal annual installments of 2,500 shares over a four-year period, with the first installment vesting on August 8, 2018, which is the one-year anniversary of the grant date. Consists of (x) 30,407 shares of common stock, (y) the unvested amount of previously-awarded restricted share units that vest in two equal installments of 43,700 shares, with the next installment vesting on July 26, 2018 and the final installment vesting on July 26, 2019 and (z) the unvested amount of the restricted share units that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 7,500 shares over a four-year period, with the first installment vesting at the close of business on August 8, 2018, which is the one-year anniversary of the grant date. /s/ John A. Sedor 2017-08-09