X0306 4 2017-07-27 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001531047 Miao Graham G C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 1 1 0 0 President and CFO Common Stock 2017-07-27 4 F 0 8132 3.15 D 57368 D No shares were sold - these shares were withheld by the Issuer to satisfy tax withholding requirements in connection with the insider's exercise of his withholding right following the vesting of restricted share units. Consists of (x) 13,701 shares of common stock and (y) the unvested amount of previously-awarded restricted share units that vest in two equal installments of approximately 21,833 shares, with the next installment vesting on July 26, 2018 and the final installment vesting on July 26, 2019. /s/ Graham G. Miao 2017-07-31