X0306 4 2017-01-04 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001607857 Pina Kenneth C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 0 1 0 0 S VP, Gen Counsel and Comp Off Common Stock 2017-01-04 4 A 0 5000 0 A 5000 D Stock Option (right to buy) 2.1 2017-01-04 4 A 0 15000 0 A 2027-01-04 Common Stock 15000 15000 D Represents a grant of restricted share units that vest in three equal installments of approximately 1,250 shares with the first installment vesting on the first anniversary of January 4, 2017 and the final installment vesting on the fourth anniversary of the vesting start date. The stock option vests in annual installments of approximately 3,750 shares, commencing on the first anniversary of January 4, 2017, with the final installment vesting on the fourth anniversary of the vesting start date. /s/ Michael Golembiewski, attorney-in-fact 2017-01-17