X0306 4 2016-11-21 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001236183 LEUNG GABRIEL C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 1 0 0 0 Stock Option (right to buy) 3.5 2016-11-21 4 A 0 4000 0 A 2026-11-20 Common Stock 4000 4000 D The stock option vests in annual installments of approximately 1,000 shares, commencing on the first anniversary of November 21, 2016, with the final installment vesting on the fourth anniversary of the vesting start date. /s/ Michael Golembiewski, attorney-in-fact 2016-11-22