X0306 4 2016-11-03 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001531047 Miao Graham G C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 1 1 0 0 PRESIDENT AND CFO COMMON STOCK 2016-11-03 4 A 0 65500 0 A 65500 D Stock Option (right to buy) 3.15 2016-11-03 4 A 0 95000 0 A 2026-11-02 Common Stock 95000 95000 D Represents a grant of restricted share units that vest in three equal installments of approximately 21,833 shares with the first installment vesting on the first anniversary of July 26, 2016, which is the vesting start date, and the final installment vesting on the third anniversary of the vesting start date. The stock option vests in annual installments of approximately 31,666 shares, commencing on the first anniversary of July 26, 2016, which is the vesting start date, with the final installment vesting on the third anniversary of the vesting start date. /s/ Graham G. Miao 2016-11-07