X0202 4 2008-02-20 0 0001333248 CADENCE PHARMACEUTICALS INC CADX 0001024007 GARNER CAM L C/O CADENCE PHARMACEUTICALS, INC. 12481 HIGH BLUFF DRIVE, SUITE 200 SAN DIEGO CA 92130 1 0 0 0 Common Stock 2008-02-20 4 A 0 37453 5.34 A 575888 I By Garner Family Trust Common Stock 486595 I By Garner Investments LLC 260,875 of these shares are subject to the Company's right to repurchase as of the date of this report. 7,094 shares vest and are no longer subject to the Company's right to repurchase on the 1st of each month until 1/01/2010 and approximately 4,072 vest and are no longer subject to the Company's right to repurchase on the 1st of each month until 2/01/2010. Mr. Garner is the trustee of this trust. 4,375 of these shares are subject to the Company's right to repurchase as of the date of this report, of which approximately 2,188 shares vest and are no longer subject to the Company's right to repurchase on the first day of each fiscal quarter until 07/01/2008. Mr. Garner is the managing member of Garner Investments, LLC. William R. LaRue Attorney-in-fact 2008-02-22