X0202 4 2006-12-28 0 0001172480 SANTARUS INC SNTS 0001024004 HALE DAVID F 2110 RUTHERFORD ROAD CARLSBAD CA 92008 1 0 0 0 Common Stock 2006-12-28 5 G 0 E 4000 D 138739 I By Family Trust Common Stock 2006-12-28 5 G 0 E 1000 A 2500 I By Family Trust Common Stock 2007-01-11 5 G 0 E 4000 D 134739 I By Family Trust Common Stock 2007-01-11 5 G 0 E 1000 A 3500 I By Family Trust Not applicable to this transaction. The reporting person no longer has a reportable beneficial interest in the following shares of common stock included in the reporting person's prior Form 4 dated 12/29/04: 1,500 shares of common stock owned by Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Shane M. Hale (the reporting person's son); 1,500 shares of common stock owned by Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Tara R. Hale (the reporting person's daughter); and 1,500 shares of common stock owned by Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Erin N. Hale (the reporting person's daughter). By Hale Family Trust dated February 10, 1986. By Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of David Garrett Hale (the reporting person's son). The reporting person disclaims beneficial ownership of these securities, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or any other purpose. /s/ Debra P. Crawford Attorney-in-Fact 2007-01-30