X0202 4 2004-12-27 0 0001172480 SANTARUS INC SNTS 0001024004 HALE DAVID F 2110 RUTHERFORD ROAD CARLSBAD CA 92008 1 0 0 0 Common Stock 2004-12-27 4 G 0 6000 D 145335 I By Family Trust Common Stock 2004-12-27 4 G 0 1500 A 1500 I By Family Trust Common Stock 2004-12-27 4 G 0 1500 A 1500 I By Family Trust Common Stock 2004-12-27 4 G 0 1500 A 1500 I By Family Trust Common Stock 2004-12-27 4 G 0 1500 A 1500 I By Family Trust Not applicable to this transaction. By Hale Family Trust dated February 10, 1986. By Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Tara R. Hale. The reporting person disclaims beneficial ownership of these securities, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or any other purpose. By Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Shane M. Hale. The reporting person disclaims beneficial ownership of these securities, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or any other purpose. By Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of David G. Hale. The reporting person disclaims beneficial ownership of these securities, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or any other purpose. By Michael T. Hale, as trustee, UDT December 26, 1991, for the benefit of Erin N. Hale. The reporting person disclaims beneficial ownership of these securities, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or any other purpose. /s/ David F. Hale 2004-12-29