SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* ALEXANDER JAMES E (Last) (First) (Middle) C/O ISONICS CORPORATION 5906 MCINTYRE STREET (Street) GOLDEN CO 80403 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol ISONICS CORP [ ISON ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner X Officer (give title below) Other (specify below) President
	3. Date of Earliest Transaction (Month/Day/Year) 10/18/2005
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock								135,455	I	See footnote(1)(3)
Common Stock								500,000	I	See footnote(2)(3)(8)
Common Stock,(12)	10/18/2005		S		20,000	D	$2.5	1,165,712	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option(4)(5)	$1.17							11/13/2001	11/13/2006	Common Stock	100,000		100,000	D
Stock Option(4)(6)	$1.25							03/28/2002	03/28/2007	Common Stock	20,000		20,000	D
Warrant(4)(7)	$1.25							03/28/2002	03/28/2007	Common Stock	100,000		100,000	D
Stock Option(4)(9)(10)	$4.64							02/22/2005	02/22/2015	Common Stock	100,000		100,000	D
Stock Option(4)(11)	$2.04							05/05/2005	04/18/2010	Common Stock	40,000		40,000	D

Explanation of Responses:

1. Shares held by the James and Carol Alexander Foundation, Inc.

2. Shares held by spouse.

3. The reporting person disclaims beneficial ownership of all securities held by his spouse and children and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

4. This transaction is exempt by reason of Rule 16b-3(d).

5. 20,000 shares vest on November 13, 2001, and 20,000 shares vest on November 13th of each of the years 2002, 2003, 2004, and 2005.

6. Options granted by resolution of the Compensation Committee of the Board of Directors as consideration for salary deferral. The grant of the options is subject to acceptance by the reporting person by no later than April 30, 2002, which acceptance was received.

7. Warrants to purchase 100,000 shares of common stock vest on March 28, 2002. The grant of the warrants is subject to acceptance by the reporting person by no later than Apil 30, 2002, which acceptance was received.

8. This transation is not a "sale" of securities since it is a gift by the reporting person and is therefore exempt pursuant to Rule 16b-5. There was no value received for the shares.

9. Options granted by resolution of the Compensation Committee of the Board of Directors pursuant to the 1996 Executives' Equity Incentive Plan. The grant of the options is subject to acceptance by the reporting person, which acceptance was received on February 22, 2005.

10. Such incentive stock options vest at a rate of 20,000 shares immediately on the date of the grant (February 22, 2005) and 20,000 shares on each anniversary of the grant date in each of years 2006, 2007, 2008 and 2009.

11. Non-qualified options granted by resolution of the Compensation Committee of the Board of Directors pursuant to the 2005 Stock Option Plan. The grant of the options is subject to acceptance by the reporting person, which acceptance was received on May 5, 2005.

12. Shares sold pursuant to a Rule 10b5-1 plan. Mr. Alexander was notified of the sale on October 18, 2005.

	/s/ James E. Alexander	10/18/2005
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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