X0306 4 2021-03-03 0 0001490978 Schrodinger, Inc. SDGR 0001023870 SHAW DAVID E 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 0001801739 Schrodinger Equity Holdings, LLC 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 Common Stock, par value $0.01 per share 2021-03-03 4 S 0 7000 99.422 D 8850890 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 4275 100.5053 D 8846615 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 18232 101.5344 D 8828383 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 1422 102.3963 D 8826961 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 4601 103.5491 D 8822360 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 1710 104.4916 D 8820650 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 2100 105.9251 D 8818550 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-03 4 S 0 660 106.8203 D 8817890 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 600 71.3658 D 8817290 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 10710 72.5431 D 8806580 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 6299 73.5082 D 8800281 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 2160 74.3452 D 8798121 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 2399 75.5079 D 8795722 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 3112 76.6672 D 8792610 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 2110 77.5967 D 8790500 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 1690 78.3834 D 8788810 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-04 4 S 0 920 79.5627 D 8787890 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 2044 63.3864 D 8785846 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 1991 64.4069 D 8783855 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 3238 65.4179 D 8780617 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 2187 66.292 D 8778430 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 3306 67.4199 D 8775124 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 6278 68.3855 D 8768846 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 6941 69.4804 D 8761905 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 1010 70.3671 D 8760895 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 185 71.4408 D 8760710 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 1200 72.5622 D 8759510 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 1120 74.0546 D 8758390 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-03-05 4 S 0 500 74.9982 D 8757890 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 4264 I Held by D. E. Shaw Technology Development, LLC The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $99.03 to $99.99, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $100.04 to $100.96, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $101.10 to $102.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $102.12 to $103.08, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $103.12 to $104.11, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $104.135 to $105.01, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $105.56 to $106.53, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $106.57 to $107.39, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.005 to $71.91, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.01 to $73.00, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.01 to $74.00, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.011 to $74.93, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.02 to $75.99, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.06 to $77.05, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $77.06 to $78.05, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $78.07 to $78.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $79.19 to $80.06, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $62.86 to $63.84, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $63.89 to $64.85, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $64.91 to $65.88, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.915 to $66.87, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.94 to $67.92, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.96 to $68.93, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.96 to $69.87, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.00 to $70.98, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.03 to $71.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.245 to $73.19, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.59 to $74.27, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.69 to $75.44, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC. David E. Shaw, By: /s/ Charles Ardai, as Attorney-in-Fact for David E. Shaw 2021-03-05 Schrodinger Equity Holdings, LLC, By: /s/ Charles Ardai, Authorized Signatory 2021-03-05