Segment Information (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013 segment	Jun. 30, 2012	Dec. 31, 2012
Segment Information
Number of reportable segments			2
Segment Information
Total revenues from external customers	$ 643,976	$ 585,045	$ 1,278,311	$ 1,158,953
Operating (loss) income	51,510	(3,929)	99,761	42,193
Total assets	2,341,274	2,137,336	2,341,274	2,137,336	2,288,342
Goodwill impairment charge	0	17,959	0	17,959
Early Development
Segment Information
Total revenues from external customers	214,582	219,683	421,858	431,351
Operating (loss) income	21,882	(33,092)	38,439	(21,784)
Total assets	1,123,348	1,098,047	1,123,348	1,098,047
Restructuring costs	2,342	9,197	5,895	9,197
Inventory write-down		20,781		20,781
Goodwill impairment charge		17,959		17,959
Late-Stage Development
Segment Information
Total revenues from external customers	377,716	323,099	750,639	642,272
Operating (loss) income	79,500	68,027	162,449	140,466
Total assets	1,001,028	814,086	1,001,028	814,086
Restructuring costs	1,363	179	3,261	179
Other Reconciling Items
Segment Information
Total revenues from external customers	51,678	42,263	105,814	85,330
Operating (loss) income	(49,872)	(38,864)	(101,127)	(76,489)
Total assets	216,898	225,203	216,898	225,203
Restructuring costs	$ 2,308	$ 291	$ 3,027	$ 291