Facility Consolidation and Other Cost Reduction Actions (Details) (USD $)	3 Months Ended	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Early Development
Restructuring activity
Total charges		$ 30,341,000	$ 11,411,000	$ 14,069,000
Inventory write-down and charges associated with expected settlement of inventory supply agreement	10,300,000	21,168,000	10,287,000
Late-Stage Development
Restructuring activity
Total charges		1,272,000	4,990,000	7,329,000
2012 Actions
Disclosure of restructuring cost
Expected restructuring costs		50,000,000
Restructuring activity
Total charges		33,930,000
Cash payments		(15,137,000)
Other		(3,653,000)
Restructuring reserve, Balance at the end of period		15,140,000
2012 Actions | Early Development
Disclosure of restructuring cost
Expected restructuring costs		37,000,000
Restructuring activity
Total charges		30,300,000
Inventory write-down and charges associated with expected settlement of inventory supply agreement		21,200,000
2012 Actions | Late-Stage Development
Disclosure of restructuring cost
Expected restructuring costs		3,000,000
Restructuring activity
Total charges		1,300,000
2012 Actions | Corporate expenses
Disclosure of restructuring cost
Expected restructuring costs		10,000,000
Restructuring activity
Total charges		2,300,000
2012 Actions | Restructuring costs included in Selling, general and administrative expenses
Restructuring activity
Total charges		30,400,000
2012 Actions | Restructuring costs included in Depreciation and amortization
Restructuring activity
Total charges		3,500,000
2012 Actions | Employee separation costs
Disclosure of restructuring cost
Expected restructuring costs		29,000,000
Restructuring activity
Total charges		22,845,000
Cash payments		(11,835,000)
Other		226,000
Restructuring reserve, Balance at the end of period		11,236,000
2012 Actions | Lease and facility exit costs
Disclosure of restructuring cost
Expected restructuring costs		7,000,000
Restructuring activity
Total charges		3,922,000
Cash payments		(307,000)
Other		118,000
Restructuring reserve, Balance at the end of period		3,733,000
2012 Actions | Accelerated depreciation and amortization
Disclosure of restructuring cost
Expected restructuring costs		4,000,000
Restructuring activity
Total charges		3,470,000
Other		(3,470,000)
2012 Actions | Other cost
Disclosure of restructuring cost
Expected restructuring costs		10,000,000
Restructuring activity
Total charges		3,693,000
Cash payments		(2,995,000)
Other		(527,000)
Restructuring reserve, Balance at the end of period		171,000
2010 and 2011 Actions
Disclosure of restructuring cost
Cumulative restructuring costs			52,400,000
Restructuring activity
Restructuring reserve, Balance at the beginning of period		10,362,000
Total charges			24,369,000	28,030,000
Cash payments		(8,529,000)
Other		(522,000)
Restructuring reserve, Balance at the end of period	10,362,000	1,311,000	10,362,000
2010 and 2011 Actions | Early Development
Disclosure of restructuring cost
Cumulative restructuring costs			25,500,000
Restructuring activity
Total charges			11,400,000	14,100,000
2010 and 2011 Actions | Late-Stage Development
Disclosure of restructuring cost
Cumulative restructuring costs			12,300,000
Restructuring activity
Total charges			5,000,000	7,300,000
2010 and 2011 Actions | Corporate expenses
Disclosure of restructuring cost
Cumulative restructuring costs			14,600,000
Restructuring activity
Total charges			8,000,000	6,600,000
2010 and 2011 Actions | Restructuring costs included in Selling, general and administrative expenses
Disclosure of restructuring cost
Cumulative restructuring costs			47,700,000
Restructuring activity
Total charges			22,600,000	25,100,000
2010 and 2011 Actions | Restructuring costs included in Depreciation and amortization
Disclosure of restructuring cost
Cumulative restructuring costs			4,700,000
Restructuring activity
Total charges			1,800,000	2,900,000
2010 and 2011 Actions | Employee separation costs
Disclosure of restructuring cost
Cumulative restructuring costs			30,200,000
Restructuring activity
Restructuring reserve, Balance at the beginning of period		5,908,000
Total charges			12,157,000	18,051,000
Cash payments		(5,054,000)
Other		(450,000)
Restructuring reserve, Balance at the end of period	5,908,000	404,000	5,908,000
2010 and 2011 Actions | Lease and facility exit costs
Disclosure of restructuring cost
Cumulative restructuring costs			6,800,000
Restructuring activity
Restructuring reserve, Balance at the beginning of period		2,620,000
Total charges			2,010,000	4,753,000
Cash payments		(1,665,000)
Other		(48,000)
Restructuring reserve, Balance at the end of period	2,620,000	907,000	2,620,000
2010 and 2011 Actions | Accelerated depreciation and amortization
Disclosure of restructuring cost
Cumulative restructuring costs			4,600,000
Restructuring activity
Total charges			1,777,000	2,873,000
2010 and 2011 Actions | Other cost
Disclosure of restructuring cost
Cumulative restructuring costs			10,800,000
Restructuring activity
Restructuring reserve, Balance at the beginning of period		1,834,000
Total charges			8,425,000	2,353,000
Cash payments		(1,810,000)
Other		(24,000)
Restructuring reserve, Balance at the end of period	$ 1,834,000		$ 1,834,000