Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of deCODE genetics, Inc. (the “Registrant”) for the quarter ended March 31, 2008 as filed with the securities and Exchange Commission on the date hereof (the “Report”), the undersigned , Kari Stefansson, Chairman, President and Chief Executive Officer of the Registrant, and Lance Thibault, Chief Financial Officer and Treasurer of the Registrant, each hereby certifies, pursuant to 18 U.S.C. Section 1350, that: (1) the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and (2) that the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

Dated: May 9, 2008	/s/ Kari Stefansson
	Kari Stefansson
	Chairman, President and Chief
	Executive Officer
Dated: May 9, 2008	/s/ Lance Thibault
	Lance Thibault
	Chief Financial Officer and
	Treasurer