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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 WpxjYRFjUJjWtNa56Gde+4geznxg760m6LtIURSzNTggTFoVZ450pbGiE3l5n6pO
 Dv5ZER1d5vtlP/GBZupcgA==

<SEC-DOCUMENT>0001209191-03-024286.txt : 20031002
<SEC-HEADER>0001209191-03-024286.hdr.sgml : 20031002
<ACCEPTANCE-DATETIME>20031002173058
ACCESSION NUMBER:		0001209191-03-024286
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031001
FILED AS OF DATE:		20031002

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYBRIDON INC
		CENTRAL INDEX KEY:			0000861838
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				043072298
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6176795500

	MAIL ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			WYNGAARDEN JAMES B
		CENTRAL INDEX KEY:			0001022940

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27352
		FILM NUMBER:		03925134

	BUSINESS ADDRESS:	
		STREET 1:		C/O GENAERA CORP
		STREET 2:		5110 CAMPUS DR
		CITY:			PLYMOUTH MEETING
		STATE:			PA
		ZIP:			19462
		BUSINESS PHONE:		610 941 4020

	MAIL ADDRESS:	
		STREET 1:		C/O GENAERA CORP
		STREET 2:		5110 CAMPUS DRIVE
		CITY:			PLYMOUTH MEETING
		STATE:			PA
		ZIP:			19462
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-10-01</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000861838</issuerCik><issuerName>HYBRIDON INC</issuerName>        <issuerTradingSymbol>hybn</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001022940</rptOwnerCik><rptOwnerName>WYNGAARDEN JAMES B</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>3504 STONEYBROOK DRIVE</rptOwnerStreet1><rptOwnerStreet2></rptOwnerStreet2><rptOwnerCity>DURHAM</rptOwnerCity><rptOwnerState>NC</rptOwnerState><rptOwnerZipCode>27705</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeTransaction><securityTitl
e><value>Common Stock</value></securityTitle><transactionDate><value>2003-10-01</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>P</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>2813</value></transactionShares><transactionPricePerShare><value>0.9775</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>176982</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Stock Options</value></securityTitle><conve
rsionOrExercisePrice><value>1.15</value></conversionOrExercisePrice><transactionDate><value>2003-10-01</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>3750</value></transactionShares><transactionPricePerShare><value>0</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2004-10-01</value></exerciseDate><expirationDate><value>2013-10-01</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>3750</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>3750</value
></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes></footnotes><remarks></remarks><ownerSignature><signatureName>James B. Wyngaarden</signatureName><signatureDate>2003-10-01</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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