<DOCUMENT>
<TYPE>EX-2.1
<SEQUENCE>4
<FILENAME>ex2-1_110502.txt
<DESCRIPTION>STATEMENT OF CONTROL PERSON
<TEXT>
      EX-2.1 OTHERDOC
      Statement of Control Person

                                                                     Exhibit 2.1
                                                                     ----------

                             Statement of Control Person


The Statement on this Schedule 13G/A dated December 5, 2002 with respect to the
common stock par value $0.001 per share of Triangle Pharmaceuticals Inc. is
filed by Samuel D. Isaly in accordance with the provisions of Rule 13d-1(c) and
Rule 13d-1(k) respectively as a control person (HC) of Orbimed Advisors LLC and
Orbimed Advisors Inc.

Orbimed Advisors Inc. and OrbiMed Advisors LLC file this statement on Schedule
13G/A in accordance with the provisions of Rule 13d-1(b) and Rule 13d-1(k)
respectively as investment advisors (IA).

</TEXT>
</DOCUMENT>