X0407 4 2022-10-06 0001121702 YIELD10 BIOSCIENCE, INC. YTEN 0001021412 SCHULER JACK W 100 N. FIELD DRIVE SUITE 360 LAKE FOREST IL 60045 true false Common Stock 2022-10-06 4 S 0 4901 2.96 D 856115 I By Jack W. Schuler Living Trust Common Stock 2022-10-07 4 S 0 200 2.9 D 855915 I By Jack W. Schuler Living Trust Common Stock 2022-10-11 4 S 0 900 2.96 D 855015 I By Jack W. Schuler Living Trust Common Stock 2022-10-12 4 S 0 1200 2.85 D 853815 I By Jack W. Schuler Living Trust Common Stock 2022-10-13 4 S 0 3000 2.88 D 850815 I By Jack W. Schuler Living Trust Common Stock 2022-10-14 4 S 0 3000 3.2 D 847815 I By Jack W. Schuler Living Trust Common Stock 2022-10-17 4 S 0 25343 3.34 D 822472 I By Jack W. Schuler Living Trust Common Stock 2022-10-18 4 S 0 13822 3.35 D 808650 I By Jack W. Schuler Living Trust Common Stock 2022-10-19 4 S 0 4259 3.22 D 804391 I By Jack W. Schuler Living Trust Common Stock 2022-10-20 4 S 0 4200 3.14 D 800191 I By Jack W. Schuler Living Trust Common Stock 2022-10-21 4 S 0 20338 3.09 D 779853 I By Jack W. Schuler Living Trust Common Stock 2022-10-24 4 S 0 4625 3.06 D 775228 I By Jack W. Schuler Living Trust Common Stock 2022-10-25 4 S 0 3141 3.07 D 772087 I By Jack W. Schuler Living Trust Common Stock 2022-10-26 4 S 0 7420 3.03 D 764667 I By Jack W. Schuler Living Trust Common Stock 2022-10-27 4 S 0 4000 3.03 D 760667 I By Jack W. Schuler Living Trust Common Stock 2022-10-28 4 S 0 4158 3.01 D 756509 I By Jack W. Schuler Living Trust Common Stock 2022-10-31 4 S 0 9851 3.01 D 746658 I By Jack W. Schuler Living Trust Common Stock 2022-11-01 4 S 0 3000 2.97 D 743658 I By Jack W. Schuler Living Trust Common Stock 2022-11-02 4 S 0 3000 2.81 D 740658 I By Jack W. Schuler Living Trust Common Stock 2022-11-04 4 S 0 1400 2.53 D 739258 I By Jack W. Schuler Living Trust Common Stock 2022-11-07 4 S 0 3000 2.45 D 736258 I By Jack W. Schuler Living Trust Common Stock 2022-11-08 4 S 0 3000 2.49 D 733258 I By Jack W. Schuler Living Trust Common Stock 2022-11-09 4 S 0 3400 2.41 D 729858 I By Jack W. Schuler Living Trust Common Stock 2022-11-14 4 S 0 3000 2.7 D 726858 I By Jack W. Schuler Living Trust Common Stock 2022-11-15 4 S 0 3000 2.72 D 723858 I By Jack W. Schuler Living Trust Common Stock 2022-11-28 4 S 0 3000 2.44 D 720858 I By Jack W. Schuler Living Trust Common Stock 2022-11-29 4 S 0 3000 2.47 D 717858 I By Jack W. Schuler Living Trust Common Stock 2022-11-30 4 S 0 3000 2.36 D 714858 I By Jack W. Schuler Living Trust Common Stock 2022-12-01 4 S 0 3000 2.33 D 711858 I By Jack W. Schuler Living Trust Common Stock 2022-12-02 4 S 0 3000 2.19 D 708858 I By Jack W. Schuler Living Trust This late filing is due to an inadvertent administrative error. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust (the "Living Trust"), and in such capacity may be deemed to beneficially own the Common Stock held by the Living Trust. /s/ Jack W. Schuler 2023-05-09