X0306 4 2016-01-26 0 0000926617 VERMILLION, INC. VRML 0001021412 SCHULER JACK W C/O VERMILLION, INC. 12117 BEE CAVES RD BLDG 3 STE 100 AUSTIN TX 78738 0 0 1 0 Common Stock, par value $0.001 per share 2016-01-26 4 P 0 700 1.60 A 2154896 I See footnote Common Stock, par value $0.001 per share 2016-01-27 4 P 0 1750 1.59 A 2156646 I See footnote Common Stock, par value $0.001 per share 6673029 D The purchase reported in column 4 is a weighted average price. The shares were purchased in multiple transactions ranging from $1.57 to $1.60. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The purchase reported in column 4 is a weighted average price. The shares were purchased in multiple transactions ranging from $1.58 to $1.60. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. These shares of common stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust. /s/ Jack W. Schuler 2016-01-28