Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2019

Summary of Product Revenue by Geographical Locations of Customers

Product revenue by geographical locations of customers during the years ended December 31, 2019, 2018 and 2017, were as follows (in thousands):


	Year Ended December 31,
	2019		2018		2017
Product revenue:
Europe, Middle East and Africa	$	52,499	$	46,974	$	36,241
North America		20,936		12,696		6,325
Other		1,214		1,238		1,002
Total product revenue	$	74,649	$	60,908	$	43,568

Computation of Basic and Diluted Net Loss per Share

The following table sets forth the reconciliation of the numerator and denominator used in the computation of basic and diluted net loss per share for the years ended December 31, 2019, 2018 and 2017 (in thousands, except per share amounts):

	Year Ended December 31,
	2019			2018			2017
Numerator for Basic and Diluted:
Net loss used for basic calculation	$	(71,244	)	$	(57,564	)	$	(60,585	)
Denominator:
Basic weighted average number of shares outstanding		139,831			131,663			108,221
Effect of dilutive potential shares		—			—			—
Diluted weighted average number of shares outstanding		139,831			131,663			108,221
Net loss per share:
Basic and diluted	$	(0.51	)	$	(0.44	)	$	(0.56	)

Anti-Dilutive Effect of Common Shares

The table below presents potential shares that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the years ended December 31, 2019, 2018 and 2017 (shares in thousands):

	2019		2018		2017
Weighted average number of anti-dilutive potential shares:
Stock options		17,401		18,031		17,373
Restricted stock units		3,361		1,902		1,225
Employee stock purchase plan rights		72		20		21
Total		20,834		19,953		18,619