CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Operating activities
Net loss	$ (36,354)	$ (27,167)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,908	788
Stock-based compensation	6,017	4,908
Non-cash interest expense	247	537
Loss on disposal of property and equipment	14	5
Changes in operating assets and liabilities:
Accounts receivable	(4,680)	1,027
Inventories	(3,977)	1,458
Other assets	1,817	(1,587)
Accounts payable	3,229	154
Accrued liabilities and other non-current liabilities	(3,410)	554
Manufacturing and development obligations	(38)	(148)
Deferred product revenue	167	216
Net cash used in operating activities	(35,060)	(19,255)
Investing activities
Capital expenditures	(6,516)	(145)
Purchases of investments	(27,728)	(75,462)
Proceeds from maturities and sale of investments	43,000	24,002
Net cash provided by (used in) investing activities	8,756	(51,605)
Financing activities
Net proceeds from equity incentives	1,270	4,912
Net proceeds from public offering	6,783	69,117
Net proceeds from revolving line of credit	4,496
Proceeds from loans	39,433
Repayment of debt	(31,045)	(65)
Net cash provided by financing activities	20,937	73,964
Net (decrease) increase in cash, cash equivalents and restricted cash	(5,367)	3,104
Cash, cash equivalents and restricted cash, beginning of period	31,587	13,930
Cash, cash equivalents and restricted cash, end of period	$ 26,220	$ 17,034