CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 29,002	$ 28,859
Short-term investments	71,426	88,718
Accounts receivable	13,756	8,752
Inventories	15,778	13,539
Prepaid and other current assets	4,958	7,034
Total current assets	134,920	146,902
Non-current assets:
Property and equipment, net	16,089	8,130
Goodwill	1,316	1,316
Operating lease right-of-use assets	15,631
Intangible assets, net	284	334
Restricted cash	2,725	2,728
Other assets	4,961	4,050
Total assets	175,926	163,460
Current liabilities:
Accounts payable	20,912	18,595
Accrued liabilities	18,397	19,800
Manufacturing and development obligations	5,962	5,928
Debt – current		7,857
Operating lease liabilities – current	1,560
Deferred product revenue – current	763	498
Total current liabilities	47,594	52,678
Non-current liabilities:
Debt – non-current	39,433	22,013
Operating lease liabilities – non-current	19,311
Other non-current liabilities	88	4,250
Total liabilities	106,426	78,941
Commitments and contingencies
Stockholders' equity:
Common stock	138	136
Additional paid-in capital	867,091	863,531
Accumulated other comprehensive loss	(70)	(281)
Accumulated deficit	(797,659)	(778,867)
Total stockholders' equity	69,500	84,519
Total liabilities and stockholders' equity	$ 175,926	$ 163,460