Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2018

Accounting Policies [Abstract]

Summary of Product Revenue by Geographical Locations of Customers

Product revenue by geographical locations of customers during the three and nine months ended September 30, 2018 and 2017, were as follows (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2018		2017		2018		2017
Product revenue:
Europe, Middle East and Africa	$	11,866	$	9,045	$	34,890	$	22,793
North America		3,117		1,524		8,653		3,872
Other		416		228		840		663
Total product revenue	$	15,399	$	10,797	$	44,383	$	27,328

Anti-Dilutive Effect of Common Shares

The table below presents potential shares that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the three and nine months ended September 30, 2018 and 2017 (shares in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2018		2017		2018		2017
Weighted average number of anti-dilutive potential shares:
Stock options		17,882		17,629		18,137		17,424
Restricted stock units		1,989		1,313		1,865		1,211
Employee stock purchase plan rights		3		—		2		11
Total		19,874		18,942		20,004		18,646