CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Operating activities
Net loss	$ (49,099)	$ (49,405)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,359	1,394
Stock-based compensation	7,008	5,966
Non-cash interest expense	282	820
Deferred income taxes	19	18
Non-cash tax expense from other unrealized loss on available-for-sale securities	3,825	1,246
Gain on sale of investment in marketable equity securities	(3,466)
Changes in operating assets and liabilities:
Accounts receivable	(3,608)	(1,647)
Inventories	(1,800)	(1,432)
Other assets	(379)	354
Accounts payable	4,022	1,562
Accrued liabilities and other non-current liabilities	(1,477)	258
Manufacturing and development obligations	600	(3,258)
Deferred product revenue	514	306
Net cash used in operating activities	(42,200)	(43,818)
Investing activities
Capital expenditures	(354)	(359)
Purchases of investments	(50,183)	(71,760)
Proceeds from maturities and sale of investments	55,566	33,500
Net cash provided by (used in) investing activities	5,029	(38,619)
Financing activities
Net proceeds from equity incentives	2,421	2,710
Net proceeds from public offering	18,840	22,146
Proceeds from loans	30,000
Repayment of debt	(19,593)	(591)
Net cash provided by financing activities	31,668	24,265
Net decrease in cash, cash equivalents and restricted cash	(5,503)	(58,172)
Cash, cash equivalents and restricted cash, beginning of period	22,744	71,630
Cash, cash equivalents and restricted cash, end of period	$ 17,241	$ 13,458