Development and License Agreements - Additional Information (Detail) $ in Thousands, € in Millions	12 Months Ended
	Dec. 31, 2016 EUR (€)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2015 EUR (€)
Licenses Agreements [Line Items]
Royalty payments on products		$ 1,900	$ 2,500	$ 3,000
Manufacturing and development obligations-current		3,282
Manufacturing and development obligations-non-current		4,542
Payments made relating to the manufacturing of the products		14,900	19,100	$ 15,000
Amounts due from Fresenius		200	1,300
Other current assets
Licenses Agreements [Line Items]
Research and development assets		4,100
Other assets
Licenses Agreements [Line Items]
Manufacturing efficiency assets		2,400
Fresenius
Licenses Agreements [Line Items]
Allocated amount for research and development activities		4,800
Manufacturing efficiency activity cost		2,400
Manufacturing and Supply Agreement
Licenses Agreements [Line Items]
Accrual for manufacturing of entity products		2,500	5,100
Manufacturing and Supply Agreement | Fresenius
Licenses Agreements [Line Items]
Accrual for manufacturing and development of entity products		$ 7,800			€ 7.2
Manufacturing and development obligations, discount rate		9.72%
Manufacturing and development obligations-current		$ 3,282			3.0
Manufacturing and development obligations-non-current		4,542			€ 4.2
Royalty
Licenses Agreements [Line Items]
Royalties owed		$ 0	$ 700
Royalty | Platelet system
Licenses Agreements [Line Items]
Royalty rate applied towards sale of products		10.00%
Royalty | Plasma system
Licenses Agreements [Line Items]
Royalty rate applied towards sale of products		3.00%
Scenario Forecast | Manufacturing and Supply Agreement | Fresenius
Licenses Agreements [Line Items]
Payments made based on the successful achievement of production volumes | €	€ 8.6