Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2012

Activity Under the Company's Equity Incentive Plans Related to Stock Options

Activity under the Company’s equity incentive plans related to stock options is set forth below (in thousands except weighted average exercise price):

	Number of Options Outstanding			Weighted Average Exercise Price per Share
Balances at December 31, 2009		6,565		$	7.38
Granted		981			2.90
Forfeited		(28	)		3.03
Expired		(309	)		19.20
Exercised		(202	)		1.62
Balances at December 31, 2010		7,007		$	6.42
Granted		2,169			2.36
Forfeited		(465	)		2.45
Expired		(1,237	)		11.52
Exercised		(112	)		0.81
Balances at December 31, 2011		7,362		$	4.70
Granted		1,782			3.68
Forfeited		(98	)		2.78
Expired		(386	)		30.44
Exercised		(156	)		1.30
Balances at December 31, 2012		8,504		$	3.40

Information Regarding Stock Options Outstanding Stock Options Vested and Expected to Vest and Stock Options Exercisable

Information regarding the Company’s stock options outstanding, stock options vested and expected to vest, and stock options exercisable at December 31, 2012, 2011 and 2010, was as follows (in thousands except weighted average exercise price and contractual term):

	Number of Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Balances at December 31, 2012
Stock options outstanding		8,504	$	3.40		6.59	$	5,433
Stock options vested and expected to vest		8,140	$	3.42		6.49	$	5,310
Stock options exercisable		5,150	$	3.77		5.43	$	3,582
Balances at December 31, 2011
Stock options outstanding		7,362	$	4.70		6.66	$	4,065
Stock options vested and expected to vest		6,900	$	4.86		6.47	$	3,835
Stock options exercisable		4,058	$	6.70		5.00	$	1,902
Balances at December 31, 2010
Stock options outstanding		7,007	$	6.42		6.22	$	2,761
Stock options vested and expected to vest		6,705	$	6.60		6.08	$	2,610
Stock options exercisable		4,323	$	8.93		4.83	$	922

Activity Under Equity Incentive Plans Related to Restricted Stock Units

Activity under the Company’s equity incentive plans related to restricted stock units is set forth below:

	Number of RSUs			Weighted Average Grant-Date Fair Value
Balances at December 31, 2009		37,867		$	6.45
Granted		76,532			1.85
Forfeited		0			0.00
Vested		(25,999	)		6.20
Balances at December 31, 2010		88,400		$	2.54
Granted		0			0.00
Forfeited		(17,727	)		1.85
Vested		(37,378	)		3.48
Balances at December 31, 2011		33,295		$	1.85
Granted		2,000			3.03
Forfeited		0			0.00
Vested		(18,650	)		1.98
Balances at December 31, 2012		16,645		$	1.85

Recognition of Stock-Based Compensation Expense

Stock-based compensation expense recognized on the Company’s consolidated statements of operations for the years ended December 31, 2012, 2011 and 2010, was as follows (in thousands):

	Year Ended December 31,
	2012		2011		2010
Stock-based compensation expense by caption:
Research and development	$	554	$	450	$	376
Selling, general and administrative		1,987		1,400		1,452
Total stock-based compensation expense	$	2,541	$	1,850	$	1,828

Weighted Average Assumptions Used to Value Stock-Based Awards

The weighted average assumptions used to value the Company’s stock-based awards for the years ended December 31, 2012, 2011 and 2010, was as follows:

	Year Ended December 31,
	2012			2011			2010
Stock Options:
Expected term (in years)		5.54			5.30			5.40
Estimated volatility		67	%		68	%		82	%
Risk-free interest rate		1.03	%		1.23	%		1.40	%
Expected dividend yield		0	%		0	%		0	%
Employee Stock Purchase Plan Rights:
Expected term (in years)		0.50			0.50			0.50
Estimated volatility		101	%		48	%		61	%
Risk-free interest rate		0.14	%		0.08	%		0.89	%
Expected dividend yield		0	%		0	%		0	%