Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss carryforwards	$ 127,184	$ 133,476
Research and development credit carryforwards	29,739	28,567
Capitalized research and development	35,861	33,571
Compensation related items	9,437	10,306
Operating leases	3,005	3,462
Other	10,928	9,823
Total deferred tax assets	216,154	219,205
Valuation allowance	(214,321)	(216,888)
Net deferred tax assets	1,833	2,317
Deferred tax liabilities:
Right-of-use assets	1,676	2,173
Other	226	209
Total deferred tax liabilities	$ 1,902	$ 2,382