Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 136,632	$ 150,523
Research and development credit carryforwards	29,242	29,411
Capitalized research and development	27,916	8,406
Compensation related items	12,014	11,951
Operating leases	3,786	4,125
Other	9,056	8,218
Total deferred tax assets	218,646	212,634
Valuation allowance	(215,903)	(209,524)
Net deferred tax assets	2,743	3,110
Deferred tax liabilities:
Right-of-use assets	2,610	2,895
Other	194	313
Total deferred tax liabilities	$ 2,804	$ 3,208