<DOCUMENT>
<TYPE>EX-2.1
<SEQUENCE>4
<FILENAME>ex2-1_021203arqule.txt
<DESCRIPTION>STATEMENT O CONTROL PERSON
<TEXT>

                                                                     Exhibit 2.1
                                                                     -----------

                             STATEMENT OF CONTROL PERSON


The Statement on this Schedule 13G/A dated February 14, 2003 with respect to the
common stock $.01 par value of ArQule, Inc. is filed by Samuel D. Isaly in
accordance with the provisions of Rule 13d-1(b) and Rule 13d-1(k), respectively,
as a control person (HC) of OrbiMed Advisors LLC and OrbiMed Advisors Inc.

Orbimed Advisors Inc. and OrbiMed Advisors LLC file this statement on Schedule
13G/A in accordance with the provisions of Rule 13d-1(b) and Rule 13d-1(k),
respectively, as investment advisors (IA).


</TEXT>
</DOCUMENT>