X0202 4 2005-11-01 0 0001018952 KOS PHARMACEUTICALS INC KOSP 0001013702 KING RICHARD C/O KOS PHARMACEUTICALS INC 1001 BRICKELL AVE 25TH FL MIAMI FL 33131 0 1 0 0 EVP, Commerical Operations Common Stock, $.01 par value 2005-11-01 4 M 0 2000 22.55 A 5743 D Common Stock, $.01 par value 2005-11-01 4 S 0 2000 59.17 D 3743 D Common Stock, $.01 par value 2005-11-01 4 M 0 1000 19.5 A 4743 D Common Stock, $.01 par value 2005-11-01 4 S 0 1000 59.17 D 3743 D Stock Option (Right to Buy) 22.55 2005-11-01 4 M 0 2000 0 D 2012-01-29 Common Stock 2000 10000 D Stock Option (Right to Buy) 19.5 2005-11-01 4 M 0 1000 0 D 2013-01-22 Common Stock 1000 79000 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2005. Includes 3,743 shares of Kos common stock acquired by reporting person in transactions exempt under Section 16 of the Exchange Act under the Kos 401(k) Plan and the Employee Stock Purchase Plan. Part of an original grant of 40,000 options, exercisable in the following amounts on the following dates: 10,000 on January 30, 2003 10,000 on January 30, 2004 10,000 on January 30, 2005 10,000 on January 30, 2006 Part of an original grant of 80,000 options, exercisable in the following amounts on the following dates: 20,000 on January 23, 2004 20,000 on January 23, 2005 20,000 on January 23, 2006 20,000 on January 23, 2007 Juan F. Rodriguez, Attorney-in-Fact 2005-11-03