X0306 4 2022-07-21 0001018399 ENTERPRISE BANCORP INC /MA/ EBTC 0001771418 SOUCIE KEITH N C/O ENTERPRISE BANCORP, INC. 222 MERRIMACK STREET LOWELL MA 01852 1 EVP-Principal Subsidiary Common Stock 2022-07-21 4 F 0 64 32.63 D 11323.9178 D Common Stock 300 I By Wife Includes 69.7811 shares acquired through dividend reinvestment on 6/1/22. /s/ John P. Clancy, Jr. as attorney-in-fact for Keith N. Soucie 2022-07-25