X0306 4 2022-03-15 0001018399 ENTERPRISE BANCORP INC /MA/ EBTC 0001825795 WORDEN ANITA R C/O ENTERPRISE BANCORP, INC. 222 MERRIMACK STREET LOWELL MA 01852 1 Common Stock 2022-03-15 4 A 0 519 0 A 1461.0537 D Includes 2.5381 shares acquired through dividend reinvestment on 6/1/21. Includes 2.6272 shares acquired through dividend reinvestment on 9/1/21. Includes 2.3323 shares acquired through dividend reinvestment on 12/1/21. Includes 2.5561 shares acquired through dividend reinvestment on 3/1/22. /s/ John P. Clancy, Jr. as attorney-in-fact for Anita R. Worden 2022-03-17