X0202 4 2006-08-17 0 0001017813 PATIENT INFOSYSTEMS INC PATY 0001351553 HICKORY VENTURE CAPITAL CORP 301 W. WASHINGTON STREET, NW SUITE 301 HUNTSVILLE AL 35801 0 0 1 0 Warrant to Purchase Common Stock 0.0032 2006-08-17 4 J 0 70129 0.00 A 2006-08-17 2014-11-17 common stock 70129 210387 I By fund through escrow Shares are beneficially owned by Hickory Venture Capital Corporation. Represents shares held in escrow for the benefit of former stockholders of CCS Consolidated, Inc. whose shares were converted into shares of the Issuer as a result of a merger between CCS Consolidated, Inc. and the Issuer. The Reporting Person previously reported the ownership of 577,652 shares of the Issuer's common stock on a Form 3 filed on February 6, 2006, which represented the minimum number of shares issuable to Hickory Venture Capital Corporation upon termination of the escrow arrangement and liquidation of the escrow account as of such date. Hickory Venture Capital Corporation holds a warrant which entitles it to purchase additional shares currently held in the escrow account, subject to the terms thereof. On February 17, 2006, the warrant became partially exercisable, and on February 22, 2006, the Reporting Person filed a Form 4 reporting the acquisition of 70,129 shares of the Issuer's common stock underlying such warrant. On May 17, 2006, the warrant became exercisable for an additional number of shares, and on May 18, 2006, the Reporting Person filed a Form 4 reporting the acquisition of an additional 70,129 shares of the Issuer's common stock underlying such warrant. On August 17, 2006, the warrant became exercisable for an additional number of shares. The shares reported herein represent an increase in the minimum number of shares issuable to Hickory Venture Capital Corporation upon termination of the escrow agreement, assuming that the warrant is exercised as to the number of shares for which the warrant is currently exercisable. /s/ J. Thomas Noojin, President 2006-08-17