SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 12b-25

                                                 Commission File Number 0-22319
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                           NOTIFICATION OF LATE FILING

     (Check One): [X] Form 10-K [ ] Form 11-K [ ] Form 20-F [ ] Form 10-Q

     Form N-SAR
     For Period Ended: December 31, 1998
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     Transition Report on Form 10-K           Transition Report on Form 10-Q
     Transition Report on Form 20-F           Transition Report on Form N-SAR
     Transition Report on Form 11-K
     For the Transition Period Ended:                                      
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     Nothing in this form shall be  construed to imply that the  Commission  has
verified any information  contained  herein. 

     If the  notification  relates  to a portion of the  filing  checked  above,
identify the item(s) to which the notification relates:
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                                     PART I
                             REGISTRANT INFORMATION

Full name of registrant     PATIENT INFOSYTEMS, INC.
                            ----------------------------------------------------
Former name if applicable
Not Applicable
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Address of principal executive office (Street and number)
46 Prince Street
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City, State and Zip Code    Rochester, NY 14607
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                                     PART II
                             RULE 12b-25 (b) AND (c)

     If the subject  report could not be filed  without  unreasonable  effort or
expense  and  the  registrant  seeks  relief  pursuant  to Rule  12b-25(b),  the
following  should be  completed.  (Check box if  appropriate.)[X]

(a)  The reasons  described in reasonable  detail in Part III of this form could
     not be eliminated without unreasonable effort or expense;
(b)  The subject annual report,  semi-annual  report,  transition report on Form
     10-K,  20-F,  11-K or form N-SAR,  or portion  thereof  will be filed on or
     before the 15th  calendar day  following  the  prescribed  due date; or the
     subject  quarterly  report or  transition  report on Form 10-Q,  or portion
     thereof  will be filed on or before the fifth  calendar day  following  the
     prescribed due date; and
(c)  The accountant's  statement or other exhibit required by Rule 12b-25(c) has
     been attached if applicable.


                                    PART III
                                    NARRATIVE

     The Company was unable to complete  the required  information  and finalize
the  necessary  documentation  in  order  to  complete  the  filing  within  the
prescribed time period without unreasonable effort or expense.


                                     PART IV
                                OTHER INFORMATION

     (1) Name and  telephone  number  of  person  to  contact  in regard to this
notification.

           Lynda Bates                          716                 242-7200
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             (Name)                          (Area Code)    (Telephone Number)

     (2) Have all other periodic  reports  required under Section 13 or 15(d) of
the Securities  Exchange Act of 1934 or Section 30 of the Investment Company Act
of 1940  during the  preceding  12 months or for such  shorter  period  that the
registrant was required to file such report(s) been filed?  If the answer is no,
identify report(s). [X] Yes [ ]   No

     (3) Is it anticipated that any significant  change in results of operations
from the corresponding  period for the last fiscal year will be reflected by the
earning statements to be included in the subject report or portion thereof?
                    [ ] Yes [X]  No

     If so, attach an explanation of the anticipated  change,  both  narratively
and  quantitatively,  and, if  appropriate,  state the reasons why a  reasonable
estimate of the results cannot be made.


PATIENT INFOSYTEMS, INC.
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                  (Name of Registrant as Specified in Charter)

     Has caused this  notification to be signed on its behalf by the undersigned
thereunto duly authorized.

Date  March 31, 1999                By /s/ Donald A. Carlberg
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                                       Donald A. Carlberg
                                       Director, President and Chief
                                        Executive Officer