Cowen & Co. 26^th Annual Health Care Conference

March 9, 2006

CareGuide/PatientInfosystems^®

Emerging Leader

In Disease and Care Management

Statements contained in this presentation that are not historical facts, including
information about management's view of the combined company's future
expectations, plans and prospects, the benefits provided by the services
offered by the combined company, the prospects for success of the merger
and the combination of the two companies, such as expected synergies and
expanded revenue opportunities, guidance as to future revenues, earnings
from continuing operations and EBITDA from continuing operations, constitute
forward-looking statements for purposes of the safe harbor provisions under
the Private Securities Litigation Reform Act of 1995. Actual results may differ
materially from historical results or those indicated by these forward-looking
statements as a result of a variety of factors including, but not limited to, risks
and uncertainties associated with the combined company's financial condition,
the continued use of the combined company’s services by its existing
customers at current or increased levels, significant concentration of the
combined company’s revenues with a limited number of customers, the
combined company’s ability to increase its business and revenue base, the
combined company’s ability to sell its products, the combined company’s ability
to compete with competitors, the growth of the healthcare market, the failure to
achieve projected operating efficiencies, higher than expected charges related
to SFAS No. 123(R) and unfavorable variances in interest rates and financing
terms, as well as other factors that are discussed in Patient Infosystems’
Annual Report on Form 10-KSB for the year ended December 31, 2004 and in
the Form 8-K/A filed with the SEC on March 8, 2006, as well as other
documents filed by Patient Infosystems with the Securities an
d Exchange Commission.

CareGuide/Patient Infosystems

An exciting, expanding company well-positioned
in one of healthcare’s fastest-growing sectors:
Disease Management/Care Management.

Addressing a major market imperative:
chronic disease

Merger created single-source provider
with differentiated offering to capitalize
on fast-growing market

Cross-selling opportunities and synergies
anticipated to result in improved financial
performance

The Market Imperative

Rising US healthcare costs:

16% of GDP in 2004, expected to grow to 20% by 2015

Increasing health insurance premiums:

Employer spending up 11.2% in 2004

Employee spending up 126% from 2000 to 2004

Aging US population:

Medicare beneficiaries doubled from 1966 to 2004

Expected to double again by 2030

Extent of chronic illness:

More than 75% of all US healthcare spending

82% of Medicare beneficiaries over 65 have at least one
chronic condition, 12% have at least five

15% of enrollees in health plans have one chronic illness,
6% have multiple or complex conditions

Continuous Care Management (CCM)

“High Intensity”

Addresses individuals with
multiple chronic and complex
illnesses

Manages conditions to avoid
emergency or acute care through:

Face-to-face visits

In-home assessments

Frequent telephone calls

Remote tele-health

Continuous Care Management

Major lever for controlling health care utilization

Compelling early results:

Up to 60% reduction in hospitalizations for one client
among members with complex medical conditions in 2005

More than 3:1 return on client investment in the early
stages of implementation for a second customer

“Hands-on” approaches that leverage medical
information and clinical algorithms

Based on timely interventions to ensure the right
care/action and avoid expensive acute care

Psychosocial factors assessed and addressed

Disease Management (DM)

“Low Intensity”

Addresses chronic illnesses ,
such as diabetes or asthma

Helps manage condition to avoid
emergency and acute care
through:

Periodic telephone contact

Education in self-management
skills

Disease Management

Subject of growing focus by
multiple payers increasingly
seeking integrated solution:

Corporations

Medicare

State Medicaid

Selected Results:

Asthma – 36% lower
healthcare costs, 67% lower ER
use

Diabetes – Emergency services
and hospitalizations cut in half

CHF – Emergency services
down 43% and hospitalizations
down 36%

The CareGuide/PATY Merger

Product focus: disease
management, utilization
management, provider
improvement

Founded 1995

HQ: Rochester, NY

IPO 1996 (Cowen & Co.)

Ticker: PATY.OB

Patient Infosystems, Inc.

Created a unique, single-source provider across entire
continuum of population health management products

CCS Consolidated, Inc.
(d/b/a CareGuide)

Product focus: Continuous
Care Management, post-
acute utilization/care
management

Founded 1995

HQ: Coral Springs, FL

Previously privately held

Historically Coordinated
Care Solutions, Inc. (CCS)

A Strong Strategic Fit

Adds synergies, size, and scale

250+ employees

50 customers in 29 states and D.C.

Combines complementary product offerings

Continuous Care Management added to
population-based disease management

Addresses all markets

Creates cross-selling opportunities across
complementary distribution channels

Health plans and work life companies added to
employer groups, TPAs, Taft-Hartley Funds
and government entities

A Differentiated Offering

Macro (health system) and micro (individual
patient) capabilities

Full continuum of population health
management products, including those aimed at
high complexity conditions

Hands-on, psychosocial, and holistic
approach to remove barriers to self-management

Individualized, information-driven, physician-
guided care management plans

Information-Driven Interventions

Analysis of Medical Data

Allows selection of individuals for care
management interventions

Risk stratification of patients

Matches intensity of care management
intervention with complexity of illness

Branching logic

Guides nurses through disease-specific
assessments and interventions with patients

Additional Products Broaden Offering

Nurse Help Line

24X7 coverage

Potential to redirect callers from ER (43%
reduction) and urgent care (37% reduction)
when unnecessary

Utilization and Care Management

Preauthorization and ongoing review of
hospitalization and other high cost medical
services

Referrals to case and disease management
programs

CareGuide@Home

In-home assessments for at-risk seniors

Medical, environmental, and psychosocial focus

Packaged in work/life benefits for employees
(children of seniors) to reduce absenteeism

InnovaCare: Provider Improvement

Works with medical office practices and medical
systems to:

Improve work flows/processes

Implement disease registries, which remind
providers when procedures are due

Implement new models that align payment with
optimal care delivery

Additional Products Broaden Offering

CareTeamConnect Continuum of Products

24X7

Nurse

Health Line

Wellness

Programs

Disease

Management

Complex

Care

Management

Increasing Intensity of Intervention

InnovaCare:

Provider

Improvement

Utilization Management

Care Management

CareGuide

@Home

Member Focused Products

Health System Focused Products

Seasoned Leadership

Board:

Albert Waxman, Ph.D., Chair (Psilos Group)

John Pappajohn, Vice Chair (Equity Dynamics)

Dan Lubin (Radius Ventures)

Mark Pacala (Essex Woodlands)

Derace Schaffer, M.D. (Partners Imaging)

Executive Team:

Chris Paterson, CEO

Glen Spence, CFO

Ann Boughtin, COO

Ileana Welte, RN, CMO

Rex Dendinger II, CIO

Roger Chaufournier, CEO, InnovaCare Division

Christine St. Andre, COO, InnovaCare Division

Merger Details

Closed 1-25-06

$12.5M PIPE raise prior to close

Retired Patient Infosystems debt

Provide working capital

63% of stock post-merger owned by former CareGuide
shareholders

67.5M common shares now outstanding

3.0M options and warrants

77% of shares subject to 18-month lock-up
(commenced 1-25-06)

Approximately $90M market cap (3-6-06)

Pro Forma Balance Sheet (9/30/05)

Cash $ 6.8

Current Assets 21.7

Total Assets 56.7

Current Liabilities 20.4

Total Liabilities 28.2

Stockholders’ equity 28.5

Dollars in millions

Pro Forma Financials (6 mos. ended 9/30/05)

Revenues $31.7

Cost of Services 28.8

Gross Profit 2.9

SG&A Expense 5.1

Depreciation / Amortization 0.9

Other Expense 0.2

Net loss - Continuing Ops $(3.3)

Dollars in millions

CY2006* Outlook

$60M to $70M revenues in forecast

$3.5M to $5.0M in EBITDA from continuing
operations in forecast

1:1 current ratio

Sufficient working capital to fund ongoing
operations and growth

*Patient Infosystems is currently on a March 31^st fiscal year and planning to move to a calendar year.
Guidance combines expected results for the last quarter of the fiscal year ending March 31, 2006
and the nine months ending December 31, 2006.

EBITDA Reconciliation (in 000’s)

How We’ll Get There

Merger synergies

Cross selling, new contract opportunities

Reduction in administrative expenses

Addition of profitable contracts

Discontinuation of unprofitable contracts

Centralization of functions

Expanding Company, Growing Market

Highly synergistic merger

End-to-end population health management
company serving a broad number of market
sectors

Well positioned to expand in one of the fastest
growing sectors in health care

Fresh business model and compelling product
line

Improved balance sheet and profitable
operations in 2006

For more information, visit our websites:

www.careguide.com

www.ptisys.com

Or Contact:

Chris Paterson or Glen Spence

954-796-3714