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                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                          ---------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                          ---------------------------

        Date of Report (Date of earliest event reported): May 29, 2001

                            PATIENT INFOSYSTEMS, INC.
                          ---------------------------
            (Exact name of registrant as specified in its charter)


           Deleware                    000-22319                16-1476509
           --------                    ---------                ----------
(State or other jurisdiction    (Commission File Number)    (I.R.S. Employer
      of incorporation)                                   Identification Number)

                           ---------------------------
                                  46 Prince St.
                               Rochester, New York
                                      14607
                           ---------------------------
               (Address of principal executive offices) (Zip code)

      Registrant's telephone number, including area code: (716) 242-7200

                                       N/A

         (Former name or former address, if changed since last report)


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ITEM 5.       OTHER EVENTS

     On June 7, 2001, Patient  Infosystems,  Inc. (the "Company") issued a press
release   concerning  the  execution  of  a  definitive   agreement  to  acquire
substantially all the assets of Health Data Solutions of Brownsburg, Indiana and
its affiliate American Care Source of Dallas, Texas.

     Attached  hereto,  and  incorporated  herein by reference  in entirety,  as
Exhibit 99.1 is a copy of the press release.

ITEM 7.       FINANCIAL STATEMENTS AND EXHIBITS

(c)  Exhibits.

99.1 Patient  Infosystems,  Inc. announces execution of asset purchase agreement
     with Health Data Solutions and American Care Source








                                   SIGNATURES



     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                       PATIENT INFOSYSTEMS, INC.


Date: June 11, 2001                    By:  /s/  Kent A. Tapper
                                          ------------------------------
                                          Name:  Kent A. Tapper
                                          Title: Principal Accounting Officer




                                  EXHIBIT INDEX


Exhibit No.              Description of the Exhibit
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   99.1        Patient  Infosystems,  Inc. announces execution of asset purchase
               agreement with Health Data Solutions and American Care Source