SCHEDULE 13G/A 0001017645 XXXXXXXX LIVE 1 Ordinary shares, par value US$0.0001 per share 12/31/2025 0001818838 Adagene Inc. 005329107 4F, BUILDING C14, NO. 218, XINGHU STREET SUZHOU INDUSTRIAL PARK JIANGSU F4 00000 Rule 13d-1(d) General Atlantic Singapore Fund Pte. Ltd. b U0 0.00 0.00 0.00 0.00 0.00 N 0 CO General Atlantic Singapore Interholdco Ltd. b D0 0.00 0.00 0.00 0.00 0.00 N 0 CO General Atlantic Partners (Bermuda) IV, L.P. b D0 0.00 0.00 0.00 0.00 0.00 N 0 PN General Atlantic Partners (Bermuda) EU, L.P. b D0 0.00 0.00 0.00 0.00 0.00 N 0 PN General Atlantic GenPar (Bermuda), L.P. b D0 0.00 0.00 0.00 0.00 0.00 N 0 PN GAP (Bermuda) L.P. b D0 0.00 0.00 0.00 0.00 0.00 N 0 PN GENERAL ATLANTIC, L.P. b DE 0.00 0.00 0.00 0.00 0.00 N 0 PN GAP Coinvestments III, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO GAP Coinvestments IV, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO GAP Coinvestments V, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO GAP Coinvestments CDA, L.P. b DE 0.00 0.00 0.00 0.00 0.00 N 0 PN General Atlantic Partners (Lux) SCSp b N4 0.00 0.00 0.00 0.00 0.00 N 0 PN General Atlantic GenPar (Lux) SCSp b N4 0.00 0.00 0.00 0.00 0.00 N 0 PN General Atlantic (Lux) S.a r.l. b N4 0.00 0.00 0.00 0.00 0.00 N 0 CO General Atlantic Singapore AI Pte. Ltd. b U0 0.00 0.00 0.00 0.00 0.00 N 0 CO Adagene Inc. 4F, Building C14, No. 218, Xinghu Street, Suzhou Industrial Park, Suzhou, Jiangsu Province, 215123, People's Republic of China This statement is being filed on behalf of each of the following persons (collectively, the "Reporting Persons"). (i) General Atlantic Singapore Fund Pte. Ltd. ("GASF"); (ii) General Atlantic Singapore Interholdco Ltd. ("GAS Interholdco"); (iii) General Atlantic Partners (Bermuda) IV, L.P. ("GAP Bermuda IV"); (iv) General Atlantic Partners (Bermuda) EU, L.P. ("GAP Bermuda EU"); (v) General Atlantic GenPar (Bermuda), L.P. ("GenPar Bermuda"); (vi) GAP (Bermuda) L.P. ("GAP (Bermuda) LP"); (vii) General Atlantic, L.P. ("GA LP"); (viii) GAP Coinvestments III, LLC ("GAPCO III"); (ix) GAP Coinvestments IV, LLC ("GAPCO IV"); (x) GAP Coinvestments V, LLC ("GAPCO V"); (xi) GAP Coinvestments CDA, L.P. ("GAPCO CDA"); (xii) General Atlantic Partners (Lux) SCSp ("GAP Lux"); (xiii) General Atlantic GenPar, (Lux) SCSp ("GA GenPar Lux"); (xiv) General Atlantic (Lux) S.a. r.l. ("GA Lux"); and (xv) General Atlantic Singapore AI Pte. Ltd. ("GA AI"). GAP Bermuda IV, GAP Bermuda EU, GAP Lux, GAPCO III, GAPCO IV, GAPCO V and GAPCO CDA are collectively referred to as the "GA Funds." The CUSIP appearing on the cover page of this statement applies to the American Depositary Shares (the "ADSs"), evidenced by American Depositary Receipts, each representing one and one quarter (1.25) ordinary shares. No CUSIP has been assigned to the ordinary shares. The address of GA LP, GAPCO III, GAPCO IV, GAPCO V, and GAPCO CDA is c/o General Atlantic Service Company, L.P., 55 East 52nd Street, 33rd Floor, New York, NY 10055. The address of GAS Interholdco, GAP Bermuda IV, GAP Bermuda EU, GenPar Bermuda, and GAP (Bermuda) LP is C/O Conyers Client Services Limited, Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda. The address of GAP Lux, GA GenPar Lux and GA Lux Sarl is 412F, route d'Esch, L-2086 Luxembourg, Grand Duchy of Luxembourg. The address of GASF and GA AI is 80 Robinson Road #02-00, Singapore, 068898. (i) GASF - Singapore (ii) GAS Interholdco - Bermuda (iii) GAP Bermuda IV - Bermuda (iv) GAP Bermuda EU - Bermuda (v) GenPar Bermuda - Bermuda (vi) GAP (Bermuda) LP - Bermuda (vii) GA LLC - Delaware (viii) GAPCO III - Delaware (ix) GAPCO IV - Delaware (x) GAPCO V - Delaware (xi) GAPCO CDA - Delaware (xii) GAP Lux - Luxembourg (xiii) GA GenPar Lux - Luxembourg (xiv) GA Lux - Luxembourg (xv) GA AI - Singapore Y As of December 31, 2025, none of the Reporting Persons beneficially owned any ADSs or ordinary shares. GA AI is wholly owned by GASF. The majority shareholder of GASF is GAS Interholdco. The members of GAS Interholdco that share beneficial ownership of the ADSs held of record by GA AI are the GA Funds. The general partner of GAP Lux is GA GenPar Lux and the general partner of GA GenPar Lux is GA Lux. The general partner of GAP Bermuda EU and GAP Bermuda IV and the sole shareholder of GA Lux is GenPar Bermuda. GAP (Bermuda) LP, which is controlled by the Management Committee of GASC MGP, LLC (the "GA Management Committee"), is the general partner of GenPar Bermuda. GA LP, which is also controlled by the GA Management Committee, is the managing member of GAPCO III, GAPCO IV and GAPCO V and the general partner of GAPCO CDA. There are six members of the GA Partnership Committee as of the date hereof. Each of the members of the GA Partnership Committee disclaims ownership of the ADSs and the underlying ordinary shares except to the extent that he has a pecuniary interest therein. The name, the business address and the citizenship of each of the members of the GA Partnership Committee and the directors of GASF and GAS Interholdco, in each case as of the date hereof, is attached hereto as Schedule A and is hereby incorporated by reference. Amount Beneficially Owned: By virtue of the relationship described above, each of the Reporting Persons may be deemed to beneficially own 0 ADSs representing 0 ordinary shares. Percentage Owned: All calculations of percentage ownership herein are based on an aggregate of 58,914,087 ordinary shares of the Issuer reported to be outstanding as of June 30, 2025, as reflected in the Issuer's Prospectus, filed with the U.S. Securities and Exchange Commission on January 9, 2026. Each of the Reporting Persons may be deemed to have the sole power to direct the voting and dispositions of the ordinary shares, the ADSs and underlying ordinary shares as indicated on such Reporting Person's cover page included herein. Each of the Reporting Persons may be deemed to share the power to direct the voting and dispositions of 0 ADSs representing 0 ordinary shares that may be deemed to be owned beneficially by each of them. Each of the Reporting Persons may be deemed to share the power to direct the voting and dispositions of 0 ADSs representing 0 ordinary shares that may be deemed to be owned beneficially by each of them. Each of the Reporting Persons may be deemed to share the power to direct the voting and dispositions of 0 ADSs representing 0 ordinary shares that may be deemed to be owned beneficially by each of them. N Y Y Y N See Item 4, which states the identity of the members of the group filing this Schedule 13G. Y Y Exhibit 1: Agreement relating to the filing of joint acquisition statements as required by Rule 13d-1(k)(1) under the Act (previously filed). (https://www.sec.gov/Archives/edgar/data/1017645/000095014222000609/eh220223350_13g-adagene.htm) General Atlantic Singapore Fund Pte. Ltd. /s/ Ong Yu Huat 02/17/2026 General Atlantic Singapore Interholdco Ltd. /s/ Michael Gosk 02/17/2026 General Atlantic Partners (Bermuda) IV, L.P. /s/ Michael Gosk 02/17/2026 General Atlantic Partners (Bermuda) EU, L.P. /s/ Michael Gosk 02/17/2026 General Atlantic GenPar (Bermuda), L.P. /s/ Michael Gosk 02/17/2026 GAP (Bermuda) L.P. /s/ Michael Gosk 02/17/2026 GENERAL ATLANTIC, L.P. /s/ Michael Gosk 02/17/2026 GAP Coinvestments III, LLC /s/ Michael Gosk 02/17/2026 GAP Coinvestments IV, LLC /s/ Michael Gosk 02/17/2026 GAP Coinvestments V, LLC /s/ Michael Gosk 02/17/2026 GAP Coinvestments CDA, L.P. /s/ Michael Gosk 02/17/2026 General Atlantic Partners (Lux) SCSp /s/ Ingrid van der Hoorn 02/17/2026 /s/ William Blackwell 02/17/2026 General Atlantic GenPar (Lux) SCSp /s/ Ingrid van der Hoorn 02/17/2026 /s/ William Blackwell 02/17/2026 General Atlantic (Lux) S.a r.l. /s/ Ingrid van der Hoorn 02/17/2026 /s/ William Blackwell 02/17/2026 General Atlantic Singapore AI Pte. Ltd. /s/ Ong Yu Huat 02/17/2026