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Equity Compensation Plans (Tables)
 12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock Option Activity

A summary of stock option activity during the year ended December 31, 2018 is as follows (share amounts in thousands):

          Weighted   Weighted     Total
          Average   Average Remaining     Aggregate
    Number of     Exercise   Contractual     Intrinsic
    Shares     Price   Life (in years)     Value
Outstanding as of December 31, 2017   12    $ 521.10    6.7    $ -  
Granted   23      63.30           
Exercised   -       -            
Cancelled   (6)     183.90    -       -  
Outstanding as of December 31, 2018   29    $ 230.10    7.8    $ -  
Vested and expected to vest as of December 31, 2018   29    $ 230.10    7.8    $ -  
Exercisable as of December 31, 2018   15    $ 375.00    6.8    $ -  

 

 

 

 
Schedule of Restricted Stock Units Activity

A summary of restricted stock unit activity during the year ended December 31, 2018 is as follows:

          Weighted
    Number of     Average Grant
    Shares     Date Fair Value
Nonvested as of December 31, 2017   24    $ 47.10 
Granted   -     $ -  
Vested   (14)   $ 49.50 
Forfeited   (1)   $ 39.60 
Nonvested as of December 31, 2018   9    $ 43.80 

 

 

 

 

 
Schedule of Valuation Assumptions for Stock Options

The following table presents the weighted average assumptions used by the Company to estimate the fair value of stock option grants using the Black-Scholes option-pricing model, as well as the resulting weighted average fair values at their issuance dates during the year ended December 31, 2018. No stock options were granted during the year ended December 31, 2017.

    2018
Risk-free interest rate   2.3%-2.3%
Volatility   98%-105%
Dividend yield   -- %
Expected term   5-6.08 years
Forfeiture rate   11.33%
Weighted average fair value   $ 49.88

 

 

 
Schedule of Stock-Based Compensation Expense

The following table summarizes the total stock-based compensation expense resulting from share-based awards recorded in the Company's consolidated statements of operations (in thousands):

      Year Ended December 31,
      2018     2017
Research and development   $ 336    $ 227 
General and administrative     965      911 
    $ 1,301    $ 1,138