Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Statement [Abstract]
License fee revenue	$ 3,600	$ 8,454	$ 941
Royalty revenue	650	36	0
Product sales	589	769	21
Contract service revenue	0	0	1,549
Total revenue	4,839	9,259	2,511
Cost of product sales	922	918	23
Cost of service revenue	0	0	2,608
Gross profit (loss)	3,917	8,341	(120)
Operating expense (income)
Research and development	14,649	21,288	5,123
General and administrative	10,516	11,418	13,554
Gain on contract settlement	0	(910)	(534)
Recovery loss on sale of subsidiary	0	(50)	(255)
Deconsolidation of former French Subsidiaries	0	(846)	(641)
Loss on disposal of assets	102	0	0
Total operating expense	25,267	30,900	17,247
Loss from continuing operations before other income (expense)	(21,350)	(22,559)	(17,367)
Other income (expense)
Interest expense, net	(845)	(339)	(727)
Loss on extinguishment of debt	0	(82)	0
Gain on sale of investment	0	0	2,600
Change in fair value of warrant liability	3,236	0	0
Other (expense) income, net	(64)	503	(376)
Total other income	2,327	82	1,497
Loss from continuing operations before income tax expense	(19,023)	(22,477)	(15,870)
Income (loss) from discontinued operations	0	691	(1,068)
Net loss	$ (19,023)	$ (21,786)	$ (16,938)
Basic and diluted loss per common share
Loss per share from continuing operations (USD per share)	$ (0.38)	$ (0.57)	$ (0.46)
Income (loss) per share from discontinued operations (USD per share)	0.00	0.02	(0.03)
Net loss per share (USD per share)	$ (0.38)	$ (0.55)	$ (0.49)
Weighted average common shares outstanding used for basic and diluted loss per share (shares)	49,728,577	39,540,409	34,413,253