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Equity (Details 2) - USD ($)
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Total $ 223,000 $ (874,760)
Research and Development Expense [Member] | Share-Based Payment Arrangement, Option [Member]    
Total 217,500 278,815
General and Administrative Expense [Member] | Share-Based Payment Arrangement, Option [Member]    
Total $ 5,500 $ (1,153,575)