Consolidated Statements of Stockholders' Equity - USD ($)	Total	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]
Balance at Dec. 31, 2013	$ 70,713,728	$ 1,287,406	$ 243,375,465	$ (173,295,941)	$ (653,202)
Balance, shares at Dec. 31, 2013		128,740,604
Exercise of warrants and options	3,105,102	$ 26,692	3,078,410
Exercise of warrants and options, shares		2,669,223
Common stock issued under equity compensation plan, net of shares withheld for taxes	(43,216)	$ 3,335	(46,551)
Common stock issued under equity compensation plan, net of shares withheld for taxes, shares		333,538
Share-based compensation	2,624,742		2,624,742
Net loss	(35,151,715)			(35,151,715)
Other comprehensive income (loss)	(52,485)				(52,485)
Balance at Dec. 31, 2014	41,196,156	$ 1,317,433	249,032,066	(208,447,656)	(705,687)
Balance, shares at Dec. 31, 2014		131,743,365
Issuance of common stock	42,850,677	$ 230,000	42,620,677
Issuance of common stock, shares		23,000,000
Common stock issued under equity compensation plan, net of shares withheld for taxes	(48,951)	$ 852	(49,803)
Common stock issued under equity compensation plan, net of shares withheld for taxes, shares		85,147
Exercise of options	30,800	$ 200	30,600
Exercise of options, shares		20,000
Share-based compensation	3,658,874		3,658,874
Net loss	(20,658,846)			(20,658,846)
Other comprehensive income (loss)	13,901				13,901
Balance at Dec. 31, 2015	67,042,611	$ 1,548,485	295,292,414	(229,106,502)	(691,786)
Balance, shares at Dec. 31, 2015		154,848,512
Common stock issued under equity compensation plan, net of shares withheld for taxes	(83,631)	$ 2,164	(85,795)
Common stock issued under equity compensation plan, net of shares withheld for taxes, shares		216,389
Exercise of options	101,092	$ 1,028	100,064
Exercise of options, shares		102,776
Share-based compensation	2,519,750		2,519,750
Net loss	(24,338,804)			(24,338,804)
Other comprehensive income (loss)	(22,484)				(22,484)
Balance at Dec. 31, 2016	$ 45,218,534	$ 1,551,677	$ 297,826,433	$ (253,445,306)	$ (714,270)
Balance, shares at Dec. 31, 2016		155,167,677