Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue:
Product sales	$ 40,318,339	$ 27,533,042	$ 13,195,577
Development revenue	10,234,486	8,892,121	7,246,080
Licensing revenue	166,188	7,242,030	3,708,938
Royalties	1,503,033	1,990,907	2,351,070
Total revenue	52,222,046	45,658,100	26,501,665
Cost of revenue:
Cost of product sales	23,908,659	12,925,129	9,359,457
Cost of development revenue	4,908,107	6,532,554	1,877,238
Total cost of revenue	28,816,766	19,457,683	11,236,695
Gross profit	23,405,280	26,200,417	15,264,970
Operating expenses:
Research and development	21,126,936	19,731,564	18,638,016
Selling, general and administrative	26,394,804	26,930,832	31,740,249
Total operating expenses	47,521,740	46,662,396	50,378,265
Operating loss	(24,116,460)	(20,461,979)	(35,113,295)
Other income (expense):
Interest income	79,783	60,469	76,661
Foreign exchange gain (loss)	(2,691)	(47,951)	156
Other, net	(199,436)	(34,385)	(90,237)
Total other expense	(122,344)	(21,867)	(13,420)
Net loss before income taxes	(24,238,804)	(20,483,846)	(35,126,715)
Income tax provision	100,000	175,000	25,000
Net loss	$ (24,338,804)	$ (20,658,846)	$ (35,151,715)
Basic and diluted net loss per common share	$ (0.16)	$ (0.14)	$ (0.27)
Basic and diluted weighted average common shares outstanding	154,992,124	146,594,079	130,549,701