X0306 4 2021-03-01 0 0001016169 ANTARES PHARMA, INC. ATRS 0001054942 APPLE ROBERT F C/O ANTARES PHARMA, INC. 100 PRINCETON SOUTH, SUITE 300 EWING NJ 08628 1 1 0 0 President & CEO Common Stock 2021-03-01 4 A 0 152763 0.00 A 2357523 D Common Stock 2021-03-01 4 F 0 66330 4.50 D 2291193 D On June 8, 2018, Mr. Apple was granted a performance stock unit award that was contingent upon achieving certain performance goals over the three-year performance period ended December 31, 2020. The number of shares acquired represent the number of shares earned upon achievement of one of the performance goals, which was certified and vested on March 1, 2021. The shares of common stock disposed represents the number of shares withheld by the company to settle tax liability in connection with the vesting of the performance stock unit award and were not actually sold. /s/Keith Muckenhirn as attorney-in-fact for Robert F. Apple 2021-03-03