Accrued and Other Current Liabilities (Tables)

12 Months Ended

Dec. 31, 2016

Accrued Liabilities, Current [Abstract]

Schedule of Accrued and Other Current Liabilities

Accrued and other current liabilities at December 31, 2016 and 2015 consist of the following:

(in thousands)	2016		2015
Accrued expenses	$	74,245	$	51,784
Payroll and related accruals	54,772		52,036
Deferred revenue	44,629		49,812
Restructuring	27,590		4,144
Accrued royalties	7,801		13,786
Cash collateral	6,984		7,826
Fair value of derivative instruments	6,089		525
Accrued interest on long-term debt	4,239		4,239
Accrued contingent consideration and milestone payments	2,957		6,995
Current portion of capital lease obligations	999		922
Total accrued and other current liabilities	$	230,305	$	192,069