| Date of Report (Date of earliest event reported)          
                  April 18, 2019 | ||
| Amarillo Biosciences, Inc. | ||
| (Exact Name of registrant as specified in its charter) | ||
| Texas | 0-20791 | 75-1974352 | 
| (State or other jurisdiction of incorporation) | (Commission File Number) | (IRS Employer Identification No.) | 
| 4134 Business Park Drive, Amarillo, Texas | 79110-4225 | |
| (Address of principal executive offices) | (Zip Code) | |
| Registrant’s telephone number, including area code   (806)
                  376-1741 | ||
| (Former name or former address, if changed since last report.) | ||
| [ ] | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) | 
| [ ] | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) | 
| [ ] | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) | 
| [ ] | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) | 
| Item 5.02. | Departure of Directors or Certain Officers. | 
|    AMARILLO BIOSCIENCES, INC. | |
| Date:  April 24, 2019 | By: /s/ Stephen T. Chen | 
| Stephen T. Chen, Ph.D. Chairman, President, CEO and CFO |