<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2023-01-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001014739</issuerCik>
        <issuerName>Option Care Health, Inc.</issuerName>
        <issuerTradingSymbol>OPCH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001961976</rptOwnerCik>
            <rptOwnerName>Whitworth Luke</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OPTION CARE HEALTH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3000 LAKESIDE DRIVE, SUITE 300N</rptOwnerStreet2>
            <rptOwnerCity>BANNOCKBURN</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60015</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Chief Operating Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>28684</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>23.9600</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2032-02-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>8104</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>25.7500</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2024-10-21</value>
            </exerciseDate>
            <expirationDate>
                <value>2031-10-21</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>24679</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>18.9700</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2031-02-23</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>12900</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>13.3400</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2030-03-09</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>36092</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Includes (i) 4,176 restricted stock units that vest as to 25% of the underlying shares of Common Stock on each of February 17, 2023, February 17, 2024, February 17, 2025 and February 17, 2026, (ii) restricted stock units that vest as to 50% of the underlying shares of Common Stock on February 23, 2023, and 25% of the underlying shares of Common Stock on each of February 23, 2024 and February 23, 2025, (iii) 9,372 restricted stock units that vest as to 50% of the underlying shares of Common Stock on each of March 9, 2023 and March 9, 2024, and (iv) 8,544 restricted stock units that vest on October 21, 2024.</footnote>
        <footnote id="F2">Stock options that vest as to 25% of the underlying shares of Common Stock on each of February 17, 2023, February 17, 2024, February 17, 2025 and February 17, 2026.</footnote>
        <footnote id="F3">Stock options that vest as to 50% of the underlying shares of Common Stock on February 23, 2023, and 25% of the underlying shares of Common Stock on each of February 23, 2024 and February 23, 2025.</footnote>
        <footnote id="F4">Stock options that vest as to 50% of the underlying shares of Common Stock on March 9, 2022, and 25% of the underlying shares of Common Stock on each of March 9, 2023 and March 9, 2024.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Collin Smyser, attorney-in-fact for Mr. Whitworth</signatureName>
        <signatureDate>2023-01-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
