X0202 4 2007-12-17 0 0001014672 CALIPER LIFE SCIENCES INC CALP 0001342137 Manyak David M 68 ELM STREET HOPKINTON MA 01748 0 1 0 0 Exec VP, Drug Discovery Svcs Common Stock 2007-12-17 4 S 0 1100 5.50 D 475021 D Common Stock 2007-12-17 4 S 0 300 5.51 D 474721 D Common Stock 2007-12-17 4 S 0 2200 5.52 D 472521 D Common Stock 2007-12-17 4 S 0 100 5.54 D 472421 D Common Stock 2007-12-17 4 S 0 100 5.56 D 472321 D Common Stock 2007-12-17 4 S 0 100 5.60 D 472221 D Common Stock 2007-12-17 4 S 0 500 5.61 D 471721 D Common Stock 2007-12-17 4 S 0 300 5.62 D 471421 D Common Stock 2007-12-17 4 S 0 100 5.63 D 471321 D Common Stock 2007-12-17 4 S 0 200 5.64 D 471121 D Common Stock 2007-12-17 4 S 0 100 5.65 D 471021 D Common Stock 2007-12-17 4 S 0 500 5.66 D 470521 D Common Stock 2007-12-17 4 S 0 100 5.72 D 470421 D Common Stock 2007-12-17 4 S 0 200 5.73 D 470221 D Common Stock 2007-12-17 4 S 0 100 5.75 D 470121 D Common Stock 2007-12-17 4 S 0 200 5.76 D 469921 D Common Stock 2007-12-17 4 S 0 300 5.79 D 469621 D Common Stock 2007-12-19 4 S 0 80 5.50 D 469541 D Common Stock 2007-12-19 4 S 1 500 5.53 D 469041 D Common Stock 2007-12-19 4 S 1 200 5.55 D 468841 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 Plan adopted by the reporting person on September 14, 2007. /s/ Peter F. McAree 2007-12-19