X0202 4 2007-10-22 0 0001014672 CALIPER LIFE SCIENCES INC CALP 0001342137 Manyak David M 68 ELM STREET HOPKINTON MA 01748 0 1 0 0 Exec VP, Drug Discovery Svcs Common Stock 2007-10-22 4 S 0 2096 5.73 D 542613 D Common Stock 2007-10-22 4 S 0 400 5.74 D 542123 D Common Stock 2007-10-22 4 S 0 1300 5.75 D 504913 D Common Stock 2007-10-22 4 S 0 200 5.77 D 540713 D Common Stock 2007-10-22 4 S 0 1000 5.78 D 539713 D Common Stock 2007-10-22 4 S 0 1504 5.79 D 538209 D Common Stock 2007-10-22 4 S 0 200 5.80 D 538009 D Common Stock 2007-10-22 4 S 0 900 5.81 D 537109 D Common Stock 2007-10-22 4 S 0 400 5.82 D 536709 D Common Stock 2007-10-22 4 S 0 400 5.83 D 536309 D Common Stock 2007-10-22 4 S 0 100 5.84 D 536209 D Common Stock 2007-10-22 4 S 0 100 5.85 D 536109 D Common Stock 2007-10-22 4 S 0 300 5.87 D 535809 D Common Stock 2007-10-22 4 S 0 100 5.88 D 535709 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 Plan adopted by the reporting person on September 14, 2007. /s/ Peter F. McAree 2007-10-23