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Credit Facilities - Deerfield Warrants (Details) - $ / shares
Mar. 31, 2019
Dec. 31, 2018
Debt Instrument [Line Items]    
Common stock issued (in shares) 10,390,524 10,387,926
2017 Deerfield Warrants    
Debt Instrument [Line Items]    
Common stock issued (in shares) 647,001  
Exercise price (usd per share) $ 92.30  
2018 Deerfield Warrants    
Debt Instrument [Line Items]    
Common stock issued (in shares) 875,001  
Exercise price (usd per share) $ 47.10