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Net Loss Per Share (Details) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Apr. 03, 2017
Nov. 02, 2015
Dec. 10, 2013
Earnings Per Share [Abstract]                            
Net loss $ (14,521,000) $ (14,273,000) $ (16,292,000) $ (21,314,000) $ (24,924,000) $ (15,245,000) $ (66,837,000) $ (47,671,000) $ (66,400,000) $ (154,677,000) $ (50,424,000)      
Shares used in computing basic and diluted net loss per share (in shares)                 83,325,000 80,976,000 67,671,000      
Basic and diluted net loss per share (in USD per share) $ (0.17) $ (0.17) $ (0.20) $ (0.26) $ (0.30) $ (0.18) $ (0.81) $ (0.62) $ (0.80) $ (1.91) $ (0.75)      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Securities excluded from calculations of net loss per share because impact would have been anti-dilutive (in shares)                 889,000 1,747,000 2,014,000      
Conversion of the Senior Notes                 6,470,000 0 0      
Deerfield Warrants                 11,939,000 14,767,000 14,767,000      
2.25% Convertible Senior Notes | Convertible Senior Notes                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Convertible notes, face amount                           $ 86,250,000
Convertible notes, stated percentage                           2.25%
3.25% Convertible Senior Notes | Convertible Senior Notes                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Convertible notes, face amount                         $ 125,000,000.0  
Convertible notes, stated percentage                         3.25%  
Facility Agreement, Due 2023 | Secured Debt                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Convertible notes, face amount                       $ 120,000,000    
Convertible notes, stated percentage   6.87%                        
Common stock options                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Securities excluded from calculations of net loss per share because impact would have been anti-dilutive (in shares)                 520,000 1,248,000 1,651,000      
Restricted stock awards                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Securities excluded from calculations of net loss per share because impact would have been anti-dilutive (in shares)                 119,000 129,000 133,000      
Restricted stock units                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Securities excluded from calculations of net loss per share because impact would have been anti-dilutive (in shares)                 250,000 370,000 230,000      
Common Stock | Facility Agreement, Due 2023, Deerfield Warrants | Facility Agreement, Due 2023                            
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                            
Number of securities called by warrants                       6,470,000    
Exercise price of warrants or rights (usd per share)                       $ 9.23