Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Cash flows from operating activities:
Net loss	$ (154,677)	$ (50,424)	$ (32,418)
Adjustments to reconcile net loss to net cash used in operating activities:
Deferred income taxes	0	(9,635)	(247)
Bad debt expense	916	107	0
Depreciation and amortization	9,149	5,886	3,283
Stock-based compensation	12,286	9,255	7,867
Change in fair value of derivative liabilities	43,831	0	0
Change in fair value of contingent consideration related to acquisition	(2,500)	100	(7,928)
Common stock issued for business development	0	0	258
Accretion of interest & amortization of deferred financing costs on convertible notes	9,539	4,842	3,719
Accretion on marketable securities	(87)	59	260
Loss on disposal of assets	123	58	180
Non-cash foreign exchange (gain) loss	2,112	(504)	5,740
Changes in operating assets and liabilities, net of assets and liabilities acquired in business combination:
Restricted cash	(2,001)	0	0
Accounts receivable and other receivables	(2,911)	(3,193)	(2,009)
Inventories	3,540	3,528	(12,489)
Prepaid expenses and other current assets	1,070	167	(632)
Accounts payable	(5,152)	8,342	2,727
Accrued payroll	7,079	(75)	1,988
Accrued expenses and other current liabilities	2,875	395	3,367
Net cash used in operating activities	(74,808)	(31,092)	(26,334)
Cash flows from investing activities:
Purchases of marketable securities	(20,976)	(82,646)	(121,015)
Maturity on marketable securities	55,850	89,690	92,197
Purchases of property and equipment	(2,796)	(4,191)	(13,461)
IntuiTrak Shonin	0	0	(1,000)
Acquisition of business, net of cash acquired of $24,012	(60,622)	0	0
Net cash (used in) provided by investing activities	(28,544)	2,853	(43,279)
Cash flows from financing activities:
Deferred financing costs	(918)	(3,617)	0
Proceeds from sale of common stock under employee stock purchase plan	3,216	2,962	2,613
Proceeds from exercise of stock options	3,129	2,871	1,776
Proceeds from convertible debt	0	125,000	0
Minimum tax withholding paid on behalf of employees for restricted stock units	(133)	(481)	(2,328)
Net cash provided by financing activities	5,294	126,735	2,061
Effect of exchange rate changes on cash and cash equivalents	(375)	(741)	(802)
Net increase (decrease) in cash and cash equivalents	(98,433)	97,755	(68,354)
Cash and cash equivalents, beginning of year	124,553	26,798	95,152
Cash and cash equivalents, end of year	26,120	124,553	26,798
Supplemental disclosure of cash flow information:
Cash paid for interest	6,262	1,957	2,018
Cash paid for income taxes	208	124	258
Non-cash investing and financing activities:
Landlord funded leasehold improvements	0	46	5,265
Fair Value of OUS Milestone Shares (note 9)	0	0	38,372
Fair value of warrants issued for business acquisition	44	0	0
Fair value of common stock issued for business acquisition	100,812	0	0
Acquisition of property and equipment included in accounts payable	$ 0	$ 155	$ 2,612